Myocardial Infarction A Multicenter, Randomized Study of Argatroban Versus Heparin as Adjunct to Tissue Plasminogen Activator (TPA) in Acute Myocardial Infarction: Myocardial Infarction With Novastan and TPA (MINT) Study
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چکیده
Ik-Kyung Jang, MD, FACC, David F. M. Brown, MD, Robert P. Giugliano, MD, SM, H. Vernon Anderson, MD, FACC,* Douglas Losordo, MD, FACC,† Jose C. Nicolau, MD,‡ Oscar P. Dutra, MD,§ Oscar Bazzino, MD, FACC,\ Victor Molina Viamonte, MD, FACC,¶ Roberto Norbady, MD,** Alvaro Sosa Liprandi, MD,†† Thomas J. Massey, BS,‡‡ Robert Dinsmore, MD, Richard P. Schwarz, JR, PHD,§§ and the MINT Investigators Boston, Massachusetts; Houston, Texas; Sao Jose Do Rio Preto, Brazil; Porto Alegre, Brazil; Buenos Aires, Argentina; Troy, New York
منابع مشابه
مراقبتهای پرستاری دردرمان با فعال کننده پلاسمینوژن بافتی
The main therapeutic objective of emergency after acute myocardial infarction (MI) is limiting the infarcted area through the opening of occluded artery, decreasing demand of myocardial oxygen and preventing MI complications.When arterial wall is injured, the collagen tissue is exposed to platelet aggregation that leads to releasing adenosine 5 diphosphate and subsequent to it, platelet adhesio...
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BACKGROUND Bolus thrombolytic therapy is a simplified means of administering thrombolysis that facilitates rapid time to treatment. TNK-tissue plasminogen activator (TNK-tPA) is a highly fibrin-specific single-bolus thrombolytic agent. METHODS AND RESULTS In TIMI 10B, 886 patients with acute ST-elevation myocardial infarction presenting within 12 hours were randomized to receive either a sing...
متن کاملEffects of Tissue Plasminogen Activator and a Comparison of Early Invasive and Conservative Strategies in Unstable Angina and Non-Q-Wave Myocardial Infarction
Background Although coronary thrombosis plays a critical role in the pathogenesis of unstable angina and non-Q-wave myocardial infarction (NQMI), the effects of thrombolytic therapy in these disorders is not clear. Also, the role of routine early coronary arteriography followed by revascularization has not been established. Methods and Results Patients (n=1473) seen within 24 hours of ischemic ...
متن کاملEffects of Tissue Plasminogen Activator and a Comparison of Early Invasive and Conservative Strategies in Unstable Angina and Non-Q-Wave Myocardial Infarction
Background Although coronary thrombosis plays a critical role in the pathogenesis of unstable angina and non-Q-wave myocardial infarction (NQMI), the effects of thrombolytic therapy in these disorders is not clear. Also, the role of routine early coronary arteriography followed by revascularization has not been established. Methods and Results Patients (n=1473) seen within 24 hours of ischemic ...
متن کاملIntravenous Heparin, Thrombolytics, and Medical Marketing
Prior to 1988, little had been written about the benefit to risk ratio of adding heparin anticoagulation to intravenous thrombolytic therapy for patients with evolving myocardial infarction, and heparin was considered to be a relatively trivial issue in the overall scheme of coronary thrombolysis. In the past 2 years, however, a considerable body of new data has been derived from intensive clin...
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تاریخ انتشار 2016